Warframe Nidus - How to Unlock and Best Build Guide (2024)

The corrupted Warframe Nidus is a great warframe that can use his parasitic abilities for survival, crowd control, and also wipe any room, excelling as an offensive character in any context or mission. His tankiness/immortality gives him great potential for soloing content, even in the endgame missions, and he can work great in a team as well.

With its new Prime variant releasing now, we can take a closer look at this masterfully versatile warframe, and how to build it.

Warframe Nidus - How to Unlock and Best Build Guide (1)

Warframe Nidus - How to Unlock and Best Build Guide (2)

Table of Contents

  • How to Obtain and Craft Nidus?
  • Nidus - Best Arsenal Loadout
  • Warframe Nidus - Best Builds

How to Obtain and Craft Nidus?

Nidus' main blueprint is acquired from “The Glast Gambit” quest, additional main blueprints can be bought from Cephalon Simaris for 50,000 Reputation. Nidus' component blueprints are acquired from Rotation C of Infested Salvage on Oestrus, Eris.

Component

Requirements/How to Obtain

Time to Build

Nidus Blueprint

The Glast Gambit Quest Reward

72 Hours

Nidus Neuroptics

Oestrus, Eris - Rotation C Salvage - Drop Chance 14.29%

12 Hours

Nidus Chassis

Oestrus, Eris - Rotation C Salvage - Drop Chance 14.29%

12 Hours

Nidus Systems

Oestrus, Eris - Rotation C Salvage - Drop Chance 14.29%

12 Hours

Read More: Warframe The Arsenal Divide - Weapons Rebalance, Reworked Mods, And New Arcanes

Warframe Nidus - Skills & Abilities

Nidus is a very tanky warframe that has the potential of just not dying thanks to his passive. His abilities not only give him great survivability but also offensive power and crowd control tools, making him a very complete warframe and a great addition to any team or solo missions.

Passive
The Infestation dwelling within Nidus mutates rapidly when used against his foes, fueling his abilities and yielding various symbiotic benefits.

Mutation Stacks are a resource unique to Nidus, indicated by the Mutation counter and gauge displayed in the lower-right on the HUD, above the ability icons. The gauge is divided into five sections which represent the number of hits dealt to enemies via Nidus' abilities. The counter at the center of the gauge keeps track of the number of Mutation stacks, capping at 100.

Upon hitting one or more enemies via Virulence or Ravenous, depending on the number of hits the sections of the gauge will light up clockwise. After a total of 5 hits, the gauge completes a cycle and the sections become unlit again, while the counter increases by 1 Mutation stack. If Nidus suffers fatal damage with at least 15 stacks of Mutation, those 15 stacks are consumed, granting him 5 seconds of invulnerability and restoring 50% of his health.

Virulence
Rupture the ground with a damaging fungal growth that steals energy from each enemy it strikes. For every five enemies hit, the Infestation mutates, multiplying its destructive force.

Stats

Stat Values

Strength

150 / 160 / 175 / 200 Damage

Duration

-

Range

10 / 11 / 13 / 16 Meters

Miscellaneous

4 Meters of fungal growth width 25% Energy refund rate per hit

Larva
Spawn an Infested pod that erupts with tendrils, latches onto nearby enemies, and pulls them in. Enemies killed while held have a chance of generating a Mutation stack.

Stats

Stat Values

Strength

-

Duration

4 / 5 / 6 / 7 Seconds

Range

8 / 9 / 10 / 12 Meters of grab radius

Miscellaneous

3 Seconds of unaffected targets release delay

Parasitic Link
Bind to a target with a parasitic link. When cast on an ally, both the host and Nidus have their Ability Strength increased. Linked enemies take some of the damage inflicted on Nidus.
Mutation Stacks Cost: 1

Stats

Stat Values

Strength

10% / 15% / 20% / 25% Strength bonus 20% / 30% / 40% / 50% Damage redirection

Duration

30 / 35 / 45 / 60 Seconds

Range

24 / 28 / 34 / 40 Meters of ally link 10 / 13 / 16 / 20 Meters of enemy link

Miscellaneous

-

Ravenous
Gluttonous maggots swarm nearby enemies, feasting until they burst with Infestation. The maggots benefit from Mutation and each enemy consumed adds to the Mutation stack.
Mutation Stacks Cost: 3

Stats

Stat Values

Strength

100 / 110 / 125 / 150 Blast damage 10 / 13 / 16 / 20 Health regeneration per second

Duration

25 / 30 / 35 / 40 Seconds

Range

4 Meters of explosion radius

Miscellaneous

8 Meters of ability diameter Number of maggots: 9 Maggot health: 1000 HP Maggot Toxin damage: 10

Warframe Nidus - How to Unlock and Best Build Guide (3)

Warframe Nidus - How to Unlock and Best Build Guide (4)

Nidus - Best Arsenal Loadout

Since Nidus’ build relies on his skills more than weapons, you can use any setup on this part. Acceltra, Epitaph, and Orthos will serve their roles perfectly, and of course, if you can afford the Prime or Vandal versions, the better. Use as many Forma on them as you see fit to achieve the desired build, and you'll be good to go!

Warframe Nidus - How to Unlock and Best Build Guide (5)

Warframe Nidus - How to Unlock and Best Build Guide (6)

Primary Weapon - Acceltra

Mod

Effect

Loadout Mod #1 - Serration

+165% Damage

Loadout Mod #2 - Split Chamber

+90% Multishot

Loadout Mod #3 - Vital Sense

+120% Critical Damage

Loadout Mod #4 - Vigilante Armaments

+60% Multishot 5% chance to enhance Critical Hits from Primary weapons

Loadout Mod #5 - Malignant Force

+60% Toxin +60% Status Chance

Loadout Mod #6 - Point Strike

+150% Critical Chance

Loadout Mod #7 - Rime Rounds

+60% Cold +60% Status Chance

Loadout Mod #8 - Fast Hands

+30% Reload Speed

Exilus Mod - Rifle Ammo Mutation

Converts unused Ammo Pickups into Primary Weapon Ammo.

Warframe Nidus - How to Unlock and Best Build Guide (7)

Warframe Nidus - How to Unlock and Best Build Guide (8)

Secondary Weapon - Epitaph

Mod

Effect

Loadout Mod #1 - Lethal Torrent

+60% Fire Rate +60% Multishot

Loadout Mod #2 - Hornet Strike

+220% Damage

Loadout Mod #3 - Barrel Diffusion

+120% Multishot

Loadout Mod #4 - Augur Pact

+90% Damage 40% Energy spent on abilities is converted to shields.

Loadout Mod #5 - Scorch

+60% Heat +60% Status Chance

Loadout Mod #6 - Frostbite

+60% Cold +60% Status Chance

Loadout Mod #7 - Pistol Gambit

+120% Critical Chance

Loadout Mod #8 - Target Cracker

+60% Critical Damage

Exilus Mod - Lethal Momentum

+40% Projectile Speed

Warframe Nidus - How to Unlock and Best Build Guide (9)

Warframe Nidus - How to Unlock and Best Build Guide (10)

Melee Weapon - Orthos

Mod

Effect

Stance Mod - Shimmering Blight

Fast spinning attacks and staggering strikes.

Loadout Mod #1 - Reach

+1.1 Range

Loadout Mod #2 - Vicious Frost

+60% Cold +60% Status Chance

Loadout Mod #3 - Virulent Scourge

+60% Toxin +60% Status Chance

Loadout Mod #4 - Volcanic Edge

+60% Heat +60% Status Chance

Loadout Mod #5 - Weeping Wounds

+40% Status Chance per Combo Multiplier

Loadout Mod #6 - Condition Overload

+120% Critical Chance (x2 for Heavy Attacks)

Loadout Mod #7 - Blood Rush

+40% Critical Chance stacks with Combo Multiplier

Loadout Mod #8 - Berserker Fury

On Melee Kill: +35% Attack Speed for 10s. Stacks up to 2x.

Warframe Nidus - Best Builds

Warframe Nidus - How to Unlock and Best Build Guide (11)

Warframe Nidus - How to Unlock and Best Build Guide (12)

Nidus - Solo Build

The idea of the build is to use Nidus’ abilities as you see fit in the moment, prioritizing obtaining stacks so you benefit from them as soon as possible. To do this, focus on powering up the Range, Duration, and Strength as much as you can without taking any negative stat as a consequence. Since Nidus doesn’t have shields you need to boost his armor and health and use Parasitic Link at all times, always. While Hunter Adrenaline should work better than Flow in later stages of the game, it’s up to you which one to use, and for dramatically better results, replace the mods in this setup with their Prime or Umbral versions.

Mod

Effect

Aura Mod - Corrosive Projection

Converts 150% of Energy spent to Shields while Overshields are inactive.

Exilus Mod - Power Drift

+15% Ability Strength +30% Chance to Resist Knockdown

Loadout Mod #1 - Stretch

+45% Ability Range

Loadout Mod #2 - Intensify

+55% Ability Strength

Loadout Mod #3 - Continuity

+30% Ability Duration

Loadout Mod #4 - Vitality

+440% Health

Loadout Mod #5 - Adaptation

When Damaged: +10% Resistance to that Damage Type for 20s. Stacks up to 90%.

Loadout Mod #6 - Steel Fiber

+110% Armor

Loadout Mod #7 - Flow

+150% Energy Max

Loadout Mod #8 - Augur Reach

+30% Ability Range. Set Bonus: 40% Energy spent on abilities is converted to shields.

And that's all you need to know about Nidus! While you're here, you can check out our useful Yareli, Gara, and Sevagoth guides, or keep an eye on our Prime Vault and Prime Access guide so you don't miss on the returning and upcoming items!

This Article's Topics

Explore new topics and discover content that's right for you!

WarframeGuides

Have an opinion on this article? We'd love to hear it!

Warframe Nidus - How to Unlock and Best Build Guide (2024)

References

Top Articles
Latest Posts
Article information

Author: Msgr. Refugio Daniel

Last Updated:

Views: 5293

Rating: 4.3 / 5 (74 voted)

Reviews: 81% of readers found this page helpful

Author information

Name: Msgr. Refugio Daniel

Birthday: 1999-09-15

Address: 8416 Beatty Center, Derekfort, VA 72092-0500

Phone: +6838967160603

Job: Mining Executive

Hobby: Woodworking, Knitting, Fishing, Coffee roasting, Kayaking, Horseback riding, Kite flying

Introduction: My name is Msgr. Refugio Daniel, I am a fine, precious, encouraging, calm, glamorous, vivacious, friendly person who loves writing and wants to share my knowledge and understanding with you.